Drug class
"Alpha1 adrenoceptor antagonist" selective for alpha1A receptors in the prostate, used to treat urinary symptoms of benign prostatic hyperplasia.
Uses
Indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH)." Explicitly "not indicated for the treatment of hypertension.
Warnings
No boxed warning is present. Key warnings include: Orthostasis/Syncope - "potential risk of syncope" with postural hypotension, dizziness (patients should "avoid situations where injury could result"); Drug Interactions - "should not be used in combination with strong CYP3A4 inhibitors" or "other alpha adrenergic blocking agents"; Priapism - "rarely...associated with priapism (persistent painful penile erection)"; Eye Surgery - Intraoperative Floppy Iris Syndrome possible during cataract/glaucoma surgery.
Side effects
Headache (19-21%), dizziness (15-17%), rhinitis/nasal symptoms (13-18%), abnormal ejaculation (8-18%, dose-dependent), infection, asthenia, back pain, diarrhea, pharyngitis.
