Drug class
Serotonin antagonist and reuptake inhibitor (SARI); 5-HT2 receptor antagonist
Uses
Trazodone hydrochloride tablets are indicated for the treatment of major depressive disorder (MDD) in adults.
Warnings
BOXED WARNING: "Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients." Close monitoring for clinical worsening and emergence of suicidal ideation is required, particularly during initial treatment months. | Serotonin syndrome risk (especially with concurrent serotonergic agents); QT interval prolongation and cardiac arrhythmias; orthostatic hypotension and syncope; increased bleeding risk with antiplatelet/anticoagulant use; priapism (prolonged penile erections); mania/hypomania activation in bipolar disorder; discontinuation syndrome upon abrupt cessation.
Side effects
"Edema, blurred vision, syncope, drowsiness, fatigue, diarrhea, nasal congestion, weight loss" (>=5% incidence, twice placebo rate). Other frequent effects include dry mouth, dizziness, nausea, and headache.
